“Unlocking the Secret: How a Balanced Diet and Lifestyle Can Lower Your Risk of Diabetic Kidney Disease”

Objectives:

There exists a potential link between oxidative stress and the onset of diabetic kidney disease (DKD). The Oxidative Balance Score (OBS), which is based on dietary and lifestyle factors, serves as a comprehensive indicator of oxidative stress. Research exploring the connection between OBS and DKD is limited. This investigation aims to assess the correlation between OBS and the likelihood of DKD among adults in the United States.

Approaches:

This investigation included 6,725 eligible participants drawn from the U.S. population via the National Health and Nutrition Examination Survey (2005-2020). Individuals with DKD were classified as those having diabetes with a urinary albumin-to-creatinine ratio ≥ 30 mg/g and/or an estimated glomerular filtration rate < 60 mL/min/1.73 m². The OBS comprises 20 composite scores based on dietary and lifestyle determinants. To examine the possible association between OBS and DKD, weighted logistic regression as well as restricted cubic spline statistical methods were utilized.

Findings:

The likelihood of DKD exhibited an inverse relationship with OBS, dietary OBS, and lifestyle OBS (p < 0.05). When compared to the lowest quartile of OBS, the adjusted odds ratios (OR) for OBS, lifestyle OBS, and dietary OBS, in the highest quartile were 0.58 (95% CI: 0.48-0.70), 0.64 (95% CI: 0.51-0.81), and 0.57 (95% CI: 0.46-0.70), respectively. A significant nonlinear association between lifestyle OBS and DKD was discovered via the RCS curve (p for nonlinearity = 0.0081), which presented an inverted 'L' shape. Employing the two-piecewise logistic regression model, a turning point in lifestyle OBS was observed at a score of 3 (p < 0.001).

Final Thoughts:

Within the U.S. population, OBS and DKD exhibit a significantly negative correlation, implying that preserving a higher OBS may diminish the risk of developing DKD.