American Diabetes Affiliation eighty fifth Scientific Classes

Combination Bimagrumab, Semaglutide Enhances Fat Loss and Muscle Preservation

In the randomized double-blind, placebo-controlled, multicenter BELIEVE trial (NCT05616013), bimagrumab (Eli Lilly and Co)—a drug indicated to fight muscle loss—mixed with semaglutide (Ozempic, Wegovy; Novo Nordisk) led to better fats loss and improved muscle retention than both therapy alone.^1,2 In the BELIEVE medical trial, researchers evaluated the consequences of bimagrumab alone and together with semaglutide in adults with obese or weight problems. A complete of 507 people have been randomly assigned to obtain semaglutide as a once-weekly subcutaneous injection and/or bimagrumab through intravenous infusion at weeks 4, 16, 28, and 40.^1,2 Presenter Penelope Montgomery, MD, of Optimal Clinical Trials, stated the first endpoint was change in physique weight from baseline, with secondary endpoints together with modifications in waist circumference, complete physique fats mass, visceral adipose tissue, and lean mass.^1,2 The outcomes demonstrated that the mix remedy led to better reductions in weight, complete and visceral fats, and markers of irritation in contrast with both therapy alone. Notably, 92.8% of the whole weight reduction from the mix remedy got here from fats mass, in contrast with 71.8% with semaglutide alone. When bimagrumab was used as a monotherapy, 100% of weight reduction was attributed to fats mass, and there was a 2.5% improve in complete lean mass.¹ The breakthroughs offered within the BELIEVE medical trial spotlight a brand new path ahead in weight problems therapy by specializing in the standard—not simply amount—of weight reduction.