Results from the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) launched right now strengthen the case for precision prevention, a technique set to revolutionize Alzheimer’s care by combining way of life adjustments with focused therapeutics primarily based on particular person danger components.
“The future lies in precision prevention,” stated Dr. Howard Fillit, Co-Founder and Chief Science Officer of the Alzheimer’s Drug Discovery Foundation. “We have seen this model succeed in cancer and heart disease, and with a growing body of evidence showing neither lifestyle nor drugs can stop Alzheimer’s alone, now is the time to double down on studying the two in combination, which will lay the path for precision medicine.”
The ADDF is driving a brand new period of medical trials that take a look at way of life and therapeutic interventions in tandem, together with Dr. Miia Kivipelto’s MET-FINGER examine, which has created a blueprint for mixture remedy research going ahead.
The U.S. POINTER examine, launched throughout the Alzheimer’s Association International Conference (AAIC) and printed concurrently within the Journal of the American Medical Association (JAMA), discovered multidomain way of life interventions supported cognitive well being in getting older populations. This builds on earlier findings from Dr. Miia Kivipelto’s unique FINGER trial, the primary to indicate the vital function of way of life adjustments in stopping dementia.
U.S. POINTER confirmed its structured high-intensity way of life interventions benefitted individuals no matter their APOE4 service standing, a genetic danger issue for Alzheimer’s illness. This contrasts findings from the FINGER examine, which confirmed profit particularly in carriers of APOE4, and additional highlights the wide-reaching impacts of way of life adjustments.
“The U.S. POINTER results validate the findings of the FINGER study in a more diverse U.S. population,” stated Dr. Kivipelto. “This is yet another proof point that lifestyle can have a tremendous impact on the brain. By developing personalized scientific approaches to match each patient’s unique biomarker profile with a combined drug and prevention plan, we are redefining how we treat and prevent Alzheimer’s.”