A brand new analysis paper was revealed in Volume 12 of Oncoscience on September 30, 2025, titled “Lifestyle and hormonal factors affecting semen quality and sperm DNA integrity: A cross-sectional study.”
In this research, Saniya Imtiyaz Chamanmalik, Rajendra B. Nerli, and Pankaja Umarane from KLE Academy of Higher Education and Research and Dr. D. Y. Patil Medical College, Hospital and Research Centre found that some life-style selections and hormone adjustments can considerably influence males’s reproductive well being. These findings are particularly essential as male infertility continues to extend in India and world wide.
Infertility impacts one in six {couples} globally, with male-related components contributing to almost half of all circumstances. This research addressed a significant analysis hole in India by inspecting how modifiable behaviors and hormone ranges affect semen high quality and the genetic integrity of sperm.
The researchers studied 278 Indian males aged 21 to 50. Nearly half of the individuals confirmed irregular semen parameters. While older age didn’t scale back semen quantity or motility, males over 40 had larger ranges of sperm DNA fragmentation, a key marker of genetic injury and lowered fertility potential.
The research discovered sturdy associations between poor life-style selections and lowered sperm operate. Tobacco and alcohol use considerably lowered sperm rely, motility, and form. Alcohol additionally elevated sperm DNA fragmentation, which might negatively have an effect on embryo improvement. Men uncovered to excessive temperatures at work had extra DNA-damaged sperm, displaying the dangerous influence of warmth. Body weight additionally performed a significant function: each underweight and chubby males had decrease semen high quality and better DNA injury in comparison with males of regular weight.
“Tobacco and alcohol use were strongly associated with reduced sperm concentration, motility, and morphology (p < 0.001).”
In addition to life-style components, the research additionally highlighted the function of hormones in male fertility. Men with low testosterone or excessive prolactin ranges had worse semen profiles. Notably, low ranges of anti-Müllerian hormone (AMH) have been strongly related to larger sperm DNA fragmentation. Since AMH is produced by cells that assist sperm improvement, it could function a helpful new marker of sperm well being. Levels of different hormones like FSH and LH remained secure, suggesting that focused hormone testing might enhance fertility evaluation.
This research used the newest World Health Organization tips for semen evaluation and included superior exams for sperm DNA fragmentation. The outcomes recommend that conventional semen testing could miss essential indicators of fertility. Including life-style analysis and hormone profiling might assist determine reproductive issues earlier and result in more practical remedies.
While the research was restricted to a single middle and didn’t embrace long-term follow-up, it supplied helpful details about the rising problem of male infertility in India. The findings assist public well being efforts to advertise more healthy life and common hormone screening. Future analysis could assist decide whether or not life-style adjustments or hormone therapies can restore sperm injury and enhance fertility outcomes.
Source:
Journal reference:
Chamanmalik, S. I., et al. (2025). Lifestyle and hormonal components affecting semen high quality and sperm DNA integrity: A cross-sectional research. Oncoscience. doi.org/10.18632/oncoscience.627