Metabolic Diseases and Lifestyle Medicine: From Mechanisms to Clinical Practice

Metabolic ailments similar to sort 2 diabetes, weight problems, and metabolic dysfunction-associated steatotic liver illness (MASLD) signify a rising world well being disaster, pushed by a mix of genetic predisposition and way of life components. Despite important progress in understanding the biology of those situations, the combination of way of life medication into mainstream prevention and administration methods stays uneven. Current analysis has highlighted the central roles of intestine microbiota dysbiosis, persistent low-grade irritation, disrupted circadian rhythms, and metabolic signaling defects within the pathogenesis of metabolic ailments. However, inconsistencies in translating these findings into efficient and equitable medical observe persist. The rising physique of proof underscores the necessity to higher perceive how way of life components affect molecular mechanisms and to develop extra sensible, scalable interventions that not solely forestall but in addition help the reversal of metabolic dysfunction in numerous populations.

This Research Topic goals to advance the interpretation of molecular and mechanistic information into sensible medical and public well being options for metabolic ailments by means of way of life medication. Central to this goal is elucidating the precise molecular underpinnings by which adjustments in diet, bodily exercise, sleep, and psychosocial stress form metabolic well being. The subject encourages investigation into novel biomarkers for illness development and intervention monitoring, evaluation of each established and rising way of life methods—together with the roles of digital well being and customized medication—and analysis of patient-centered approaches to maximise adherence and long-term efficacy. By bridging laboratory advances and real-world care, this Research Topic seeks to outline new, interdisciplinary requirements for prevention, therapy, and sustainable administration of metabolic issues.

The scope of this Research Topic spans the continuum from bench to bedside, addressing each mechanistic and utilized elements of way of life medication in metabolic well being. Manuscripts ought to focus inside the boundaries of modifiable way of life components, molecular pathways, and translational intervention approaches, excluding purely pharmacological or surgical methods. To collect additional insights into these priorities, we welcome articles addressing, however not restricted to, the next themes:
o Pathophysiological mechanisms linking weight-reduction plan, train, sleep, and stress to metabolic ailments
o Biomarkers for early detection and monitoring of lifestyle-modifiable metabolic issues
o Efficacy and mechanistic insights of structured way of life interventions (e.g., fasting-mimicking diets, high-intensity interval coaching) in reversing MASLD and sort 2 diabetes
o The utility of digital well being, AI, and wearable applied sciences in customized way of life modification
o The function of intestine microbiota and pre/probiotics in mediating the consequences of way of life
o Socioeconomic, cultural, and psychological determinants of way of life behaviors
o Strategies for integrating way of life medication into main care and well being coverage
o Economic evaluations of way of life intervention applications