This web page was created programmatically, to learn the article in its authentic location you possibly can go to the hyperlink bellow: https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1802176/fulland if you wish to take away this text from our website please contact us [ad_1] AbstractPhenotypic age (PhenoAge) is a composite biomarker that displays organic growing old by integrating indicators of immune, metabolic, liver, and kidney operate. Using 4.9 years of follow-up knowledge from 69,462 contributors within the Taiwan Biobank, this research investigated life-style and environmental components related to adjustments in PhenoAge (ΔPhenoAge: follow-up minus baseline). Partial correlation evaluation was first utilized to guage 43 life-style components. Fifteen components have been positively correlated with ΔPhenoAge, with obesity-related indices displaying the strongest correlations. Nine components have been inversely correlated, together with employment standing and dietary habits. These variables have been additional evaluated utilizing best-subset regression to determine probably the most related components. In multivariable analyses, ΔPhenoAge in males was related to dwelling alone, larger physique fats proportion, and bigger waist circumference. In girls, ΔPhenoAge was related to each day complement use, consuming supper inside 1 hour of bedtime, and better physique mass index. Exposure to incense burning was related to larger ΔPhenoAge in each sexes. Conversely, lowered consumption of fried meals, higher number of greens, decrease meat consumption, and staying on the similar job all through the profession have been related to decrease ΔPhenoAge. These outcomes recommend that a number of modifiable components are related to adjustments in organic growing old, highlighting the significance of life-style for wholesome growing old.SummaryKeywordsAging, biomarkers, DNA Methylation, Incense burning, Oxidative StressReceived02 February 2026Accepted17 April 2026 Copyright © 2026 Lin. This is an open-access article distributed beneath the phrases of the Creative Commons Attribution License (CC BY). The use, distribution or copy in different boards is permitted, supplied the unique writer(s) or licensor are credited and that the unique publication on this journal is cited, in accordance with accepted tutorial observe. No use, distribution or copy is permitted which doesn't adjust to these phrases. *Correspondence: Wan-Yu LinDisclaimer All claims expressed on this article are solely these of the authors and don't essentially signify these of their affiliated organizations, or these of the writer, the editors and the reviewers. Any product that could be evaluated on this article or declare that could be made by its producer is just not assured or endorsed by the writer. [ad_2] This web page was created programmatically, to learn the article in its authentic location you possibly can go to the hyperlink bellow: https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1802176/fulland if you wish to take away this text from our website please contact us