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Week 2 will be in the running for best early-afternoon slate of the year.
Now, Week 3 kicks off Thursday night, as the Buffalo Bills host the Miami Dolphins.
Here are the lines for every Week 3 matchup at DraftKings Sportsbook as of Sept. 15.
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(All times ET)
2025 NFL Week 3 Odds
THURSDAY, SEPT. 18
DOLPHINS @ BILLS (8:15 p.m., Prime Video)
Point spread: Bills -12.5 (Bills favored to win by 12.5 points or more, otherwise Dolphins cover)
Moneyline: Bills -800 favorites to win; Dolphins +550 underdogs to win
Total Over/Under: 49.5 points scored by both teams combined
SUNDAY, SEPT. 21
PACKERS @ BROWNS (1:00 p.m., FOX)
Point spread: Packers -9.5 (Packers favored to win by 9.5 points or more, otherwise Browns cover)
Moneyline: Packers -440 favorites to win; Browns +340 underdogs to win
Total Over/Under: 42.5 points scored by both teams combined
COLTS @ TITANS (1:00 p.m., CBS)
Point spread: Colts -3 (Colts favored to win by 3 points or more, otherwise Titans cover)
Moneyline: Colts -166 favorites to win; Titans +140 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined
BENGALS @ VIKINGS (1:00 p.m., CBS)
Point spread: Vikings -4.5 (Vikings favored to win by 4.5 points or more, otherwise Bengals cover)
Moneyline: Vikings -198 favorites to win; Bengals +164 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined
STEELERS @ PATRIOTS (1:00 p.m., CBS)
Point spread: Steelers -1.5 (Steelers favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Steelers -112 favorites to win; Patriots -108 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined
RAMS @ EAGLES (1:00 p.m., FOX)
Point spread: Eagles -3.5 (Eagles favored to win by 3.5 points or more, otherwise Rams cover)
Moneyline: Eagles -185 favorites to win; Rams +154 underdogs to win
Total Over/Under: 45.5 points scored by both teams combined
JETS @ BUCCANEERS (1:00 p.m., FOX)
Point spread: Buccaneers -7 (Buccaneers favored to win by 7 points or more, otherwise Jets cover)
Moneyline: Buccaneers -325 favorites to win; Jets +260 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined
RAIDERS @ COMMANDERS (1:00 p.m., FOX)
Point spread: Commanders -6 (Commanders favored to win by 6 points or more, otherwise Raiders cover)
Moneyline: Commanders -258 favorites to win; Raiders +210 underdogs to win
Total Over/Under: 47.5 points scored by both teams combined
FALCONS @ PANTHERS (1:00 p.m., FOX)
Point spread: Falcons -3.5 (Falcons favored to win by 3.5 points or more, otherwise Panthers cover)
Moneyline: Falcons -185 favorites to win; Panthers +154 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined
TEXANS @ JAGUARS (1:00 p.m., CBS)
Point spread: Jaguars -1.5 (Jaguars favored to win by 1.5 points or more, otherwise Texans cover)
Moneyline: Jaguars -115 favorites to win; Texans -105 underdogs to win (bet $10 to win $19.52 total)
Total Over/Under: 43.5 points scored by both teams combined
BRONCOS @ CHARGERS (4:05 p.m., CBS)
Point spread: Chargers -2.5 (Chargers favored to win by 2.5 points or more, otherwise Broncos cover)
Moneyline: Chargers -142 favorites to win; Broncos +120 underdogs to win
Total Over/Under: 45.5 points scored by both teams combined
SAINTS @ SEAHAWKS (4:05 p.m., CBS)
Point spread: Seahawks -7.5 (Seahawks favored to win by 7.5 points or more, otherwise Saints cover)
Moneyline: Seahawks -380 favorites to win; Saints +300 underdogs to win
Total Over/Under: 42.5 points scored by both teams combined
COWBOYS @ BEARS (4:25 p.m., FOX)
Point spread: Bears -1.5 (Bears favored to win by 1.5 points or more, otherwise Cowboys cover)
Moneyline: Bears -120 favorites to win; Cowboys +100 underdogs to win
Total Over/Under: 48.5 points scored by both teams combined
CARDINALS @ 49ERS (4:25 p.m., FOX)
Point spread: 49ers -1.5 (49ers favored to win by 1.5 points or more, otherwise Cardinals cover)
Moneyline: 49ers -125 favorites to win; Cardinals +105 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined
CHIEFS @ GIANTS (8:20 p.m., NBC)
Point spread: Chiefs -5.5 (Chiefs favored to win by 5.5 points or more, otherwise Giants cover)
Moneyline: Chiefs -250 favorites to win; Giants +205 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined
MONDAY, SEPT. 22
LIONS @ RAVENS (8:15 p.m., ABC/ESPN)
Point spread: Ravens -6 (Ravens favored to win by 6 points or more, otherwise Lions cover)
Moneyline: Ravens -258 favorites to win; Lions +210 underdogs to win
Total Over/Under: 51.5 points scored by both teams combined
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This web page was created programmatically, to learn the article in its authentic location you’ll be able to go to the hyperlink bellow:
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