Remission achievable for 1 in 3 Indian diabetics by intensive app-based life-style program

Nearly one-third of individuals with kind 2 diabetes (T2D) in an Indian cohort achieved remission by an intensive life-style intervention program, in accordance with a brand new examine publishing October 22, 2025, within the open-access journal PLOS One by Pramod Tripathi of Freedom from Diabetes Clinic & Diabetes Research Foundation, India, and colleagues.

Type 2 diabetes impacts greater than 72 million folks in India. While life-style interventions have proven promise for diabetes administration in Western populations, restricted knowledge exists on their effectiveness in India, the place genetic and life-style components place the inhabitants at greater threat.

In the brand new examine, researchers analyzed knowledge from 2,384 adults with T2D who enrolled in a one-year on-line intensive life-style intervention program on the Freedom from Diabetes Clinic in India between May 2021 and August 2023. The intervention, supplied by a six-member care group by a cellular utility, included a customized plant-based food regimen, structured bodily exercise, group remedy and particular person psychological counseling, and medicine administration.

Overall, 744 contributors (31.2%) achieved diabetes remission, outlined as sustaining glycated hemoglobin (HbA1c) ranges under 48 mmol/mol for not less than three months with out glucose-lowering medicines. The remission group confirmed considerably higher enhancements than the non-remission group in weight (8.5% vs. 5.2% discount), physique mass index (8.6% vs. 5.2% discount), HbA1c (15.3% vs. 12.4% discount), fasting insulin (26.6% vs. 11.4% discount), and insulin resistance (37.3% vs. 19.7% discount). People underneath 50 years of age, with greater BMI, no prior treatment use, and a shorter length of diabetes (<6 years) had been more than likely to realize remission. 

The examine was restricted by its retrospective design and lack of a management group. Because this system required a subscription and contributors who lacked observe up knowledge had been excluded from the evaluation, there could have been choice biases. However, the authors conclude {that a} important proportion of people with T2D can obtain remission by a complete, culturally tailored life-style program.

The authors add: “Our research demonstrates that nearly one-third of individuals with type 2 diabetes can achieve remission through a scientifically designed, culturally tailored, and structured lifestyle intervention. This represents the first large-scale evidence from India highlighting the potential of intensive lifestyle modification in achieving type 2 diabetes remission.”

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Citation: Tripathi P, Kadam N, Kathrikolly T, Tiwari D, Vyawahare A, Sharma B, et al. (2025) Type 2 diabetes remission and its predictors in an Indian cohort: A retrospective evaluation of an intensive life-style intervention program. PLoS One 20(10): e0333114.

Author nations: India

Funding: The writer(s) acquired no particular funding for this work.