Lifestyle

Affected person-initiated way of life modifications following receipt of genetic check leads to a predominantly marginalized inhabitants

- by fooshya - Leave a Comment

This web page was created programmatically, to learn the article in its unique location you’ll be able to go to the hyperlink bellow:
https://pubmed.ncbi.nlm.nih.gov/41093769/
and if you wish to take away this text from our web site please contact us



Affiliations

Item in Clipboard

Marian J Gilmore et al.


J Genet Couns.


2025 Oct.

Abstract

Genetic testing for most cancers predisposition and different actionable findings goals to enhance well being outcomes by informing sufferers and practitioners about genetic illness dangers and guiding choices on risk-reducing actions. This research explored patient-initiated way of life modifications following genetic testing in a research inhabitants who predominantly screened optimistic on a hereditary danger evaluation most cancers software previous to genetic testing, with a big proportion of people from marginalized teams with traditionally restricted entry to genetic companies. A survey was administered to 761 research members 6 months after outcome disclosure to seize initiation of way of life modifications (eating regimen, train, smoking cessation). Initiation of modifications was assessed for affiliation with patient-specific elements. Five hundred and fifty-six people accomplished surveys; 75% met standards for belonging to a marginalized group. Among respondents, 20.5% reported not less than one way of life change; primarily in eating regimen (17.1%) and train (13.7%). Making a life-style change was related to having a private most cancers historical past and better perceived private utility however not genetic discovering, being a member of a marginalized group, or gender. Most members with a private most cancers historical past didn’t obtain a optimistic discovering in a most cancers danger gene, probably motivating them to make way of life modifications in contrast with members with out a private most cancers historical past.


Keywords:

genetic check outcomes; hereditary most cancers; marginalized populations; affected person‐initiated modifications.

PubMed Disclaimer

References

REFERENCES

    1. Amendola, L. M., Berg, J. S., Horowitz, C. R., Angelo, F., Bensen, J. T., Biesecker, B. B., Biesecker, L. G., Cooper, G. M., East, Okay., Filipski, Okay., Fullerton, S. M., Gelb, B. D., Goddard, Okay. A. B., Hailu, B., Hart, R., Hassmiller‐Lich, Okay., Joseph, G., Kenny, E. E., Koenig, B. A., … Jarvik, G. P. (2018). The medical sequencing proof‐producing analysis consortium: Integrating genomic sequencing in various and medically underserved populations. American Journal of Human Genetics, 103(3), 319–327.

    1. Amendola, L. M., Shuster, E., Leo, M. C., Dorschner, M. O., Rolf, B. A., Shirts, B. H., Gilmore, M. J., Okuyama, S., Zepp, J. M., Kauffman, T. L., Mittendorf, Okay. F., Bellcross, C., Jenkins, C. L., Joseph, G., Riddle, L., Syngal, S., Ukaegbu, C., Goddard, Okay. A. B., Wilfond, B. S., & Jarvik, G. P. (2022). Laboratory‐associated outcomes from integrating an accessible supply mannequin for hereditary most cancers danger evaluation and genetic testing in populations with obstacles to entry. Genetics in Medicine, 24(6), 1196–1205.

    1. AnVIL Project. (2025). CSER Resources.

    1. Brittain, H. Okay., Scott, R., & Thomas, E. (2017). The rise of the genome and personalised drugs. Clinical Medicine (London, England), 17(6), 545–551.

    1. Chlebowski, R. T., Aragaki, A. Okay., Anderson, G. L., Pan, Okay., Neuhouser, M. L., Manson, J. E., Thomson, C. A., Mossavar‐Rahmani, Y., Lane, D. S., Johnson, Okay. C., Wactawski‐Wende, J., Snetselaar, L., Rohan, T. E., Luo, J., Barac, A., & Prentice, R. L. (2020). Dietary modification and breast most cancers mortality: Long‐time period comply with‐up of the Women’s Health Initiative randomized trial. Journal of Clinical Oncology, 38(13), 1419–1428.

MeSH phrases

LinkOut – extra sources

  • Full Text Sources

  • Medical

  • Miscellaneous