Exploratory Machine Studying Methods to Assess a Novel Individualized Lifestyle Intervention on Weight and Body Composition with or With no Swallowable Intragastric Balloon

Background/goals:

This research assesses the results of an individualized life-style intervention (LI) on physique composition (BC), each with and with out the addition of the Allurion™ swallowable intragastric balloon (SIGB).

Methods:

In this case-controlled research, a complete of 1,143 sufferers with a BMI ≥ 30 kg/m² participated in a 36-week LI. Of these, 267 acquired the SIGB (LI + SIGB group), whereas 876 underwent the LI alone (LI group). The LI protocol featured customized dietary plans with every day protein consumption targets, train targets, and common telehealth follow-ups. The SIGB was ingested with out endoscopy or anesthesia and handed naturally roughly 16 weeks post-placement. Body composition was assessed utilizing bioimpedance at a number of time factors. We in contrast % complete physique weight reduction (%TBWL), fats mass loss (%FML), muscle mass loss (%MML), and visceral fats loss (%VFL) between the teams.

Results:

The teams have been age-matched however differed in intercourse and BMI. At 16 weeks, the LI + SIGB group demonstrated considerably greater imply %TBWL (16.11 ± 5.06 vs. 10.22 ± 6.09, p < 0.001), %FML (27.64 ± 9.78 vs. 15.34 ± 10.37, p < 0.001), and %VFL (17.60 ± 7.33 vs. 13.80 ± 8.57, p < 0.001). While %MML was additionally greater within the LI + SIGB group (6.57 ± 7.64 vs. 3.55 ± 12.45, p < 0.001), the speed of %FML was greater than double the speed of %MML in each teams, suggesting favorable physique composition modifications. A considerably larger proportion of sufferers within the LI + SIGB group achieved key weight reduction thresholds of > 5%, > 10%, and > 20% TBWL at 16 weeks (all p < 0.001).

Conclusions:

The SIGB considerably enhanced complete physique weight reduction, fats loss, and visceral fats loss when used as an adjunct to an intensive life-style intervention. While the SIGB did result in larger muscle mass loss, the general physique composition modifications have been favorable, with fats loss far outpacing muscle loss in each intervention teams. These findings counsel that the SIGB is a protected and efficient software to speed up early weight reduction, notably fats loss, when mixed with a sturdy life-style protocol.