Lively way of life tied to diminished visible discipline decline in main open angle glaucoma

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Je Hyun Seo, MD, PhD, and colleagues reported that elevated quantities of time spent in bodily exercise are impartial predictors of a slower price of visible discipline imply deviation (VF MD) loss in sufferers with main open angle glaucoma (POAG). They revealed their leads to the Journal of Glaucoma.¹

Seo is the primary research writer from the Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, CA, and the Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, South Korea. Seo was joined on this research by colleagues from the Department of Ophthalmology, Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, and the Department of Ophthalmology and Vision Sciences, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, additionally participated within the research.

Physical exercise research strategies and outcomes

The investigators performed this longitudinal research with the purpose of figuring out how bodily exercise impacts the development of the VF injury in sufferers with POAG.

The research contributors with POAG had undergone 5 or extra visits and had 2 or extra years of follow-up VFs. All sufferers accomplished a bodily exercise questionnaire at baseline.

The investigators defined that the bodily exercise ranges had been assessed utilizing the bodily exercise index (PAI), metabolic equivalents of activity (MET)-minutes, and strolling tempo.

Seo and colleagues reported that 131 eyes of 80 sufferers (median affected person age, 68.6 years; interquartile vary [IQR]: 59.3–77.8 years) with POAG had been included; the median follow-up time was 4.9 years (IQR: 4.0–6.7 years). The median baseline VF MD was −3.5 (IQR: −8.3 to −1.3).

The univariable evaluation revealed that slower VF MD loss was related to the energetic PAI class (0.30 decibel [dB]/yr; 95% confidence interval [CI]: 0.01–0.58 vs. the inactive PAI class; P=0.041) and better quantities of bodily exercise (0.14 [95% CI: 0.01–0.27] dB/yr per 1,000 MET-minutes; P=0.036).

They didn’t discover a important affiliation between the speed of VF MD loss for the baseline VF MD (P=0.263) and strolling tempo (P>0.05).

The multivariable evaluation, which included the glaucoma severity and different covariates, discovered that the slower VF MD loss was related to greater quantities of bodily exercise (0.15 [95% CI: 0.02–0.28] dB/yr per 1,000 MET-minutes; P=0.024).

The investigators concluded the upper quantities of bodily exercise are impartial predictors of a slower price of VF MD loss. They suggested that additional analysis ought to discover whether or not elevated charges of bodily exercise shield in opposition to glaucoma development.

Related analysis

Another research out of the Wilmer Eye Institute, The Johns Hopkins University, Baltimore, additionally reported the useful results of bodily exercise on slower VF loss.²

First writer Moon Jeong Lee, MD, and colleagues performed a longitudinal observational research that included older adults who had been glaucoma suspects or had frank glaucoma.

Participants wore accelerometers for 1 week to measure the each day common steps, minutes of moderate-to-vigorous exercise (MVPA), and minutes of non-sedentary exercise. The predominant consequence was the pointwise modifications within the VF sensitivity related to bodily exercise.

A complete of 141 sufferers (imply age, 64.9 ± 5.8 years) had been enrolled. The eye MD on the time of bodily exercise evaluation was −6.6 dB and the common variety of each day steps was 5,613 ± 3,158. The unadjusted common price of VF loss was 0.36 dB/yr (95% CI: −0.37, −0.35). Multivariable evaluation confirmed that slower VF loss was noticed when sufferers recorded greater numbers of steps (+0.007 dB/yr/1,000 each day steps, P<0.001), extra moderate-to-vigorous exercise (+0.003 dB/yr/10 extra minutes of MVPA each day, P<0.001), and extra non-sedentary exercise (+0.007 dB/yr/30 extra minutes of non-sedentary time each day, P=0.005).

The components that had been related to a quicker price of VF loss included older age, non-Caucasian race, glaucoma surgical procedure, cataract surgical procedure, and reasonable baseline VF injury (−6 dB≥MD>– 12 dB) versus delicate VF injury (MD>−6 dB). Similar associations between the accelerometer-measured bodily exercise at baseline and charges of VF loss had been noticed over different time intervals (eg, inside 1, 3, and 5 years of exercise evaluation), the authors reported.

They concluded, “Increased walking, greater time spent doing moderate-to-vigorous physical activity, and more time spent in non-sedentary activity were associated with slower rates of VF loss in a treated population of glaucoma patients, with an additional 5,000 daily steps or 2.6 hours of non-sedentary physical activity decreasing the average rate of VF loss by roughly 10%. Future prospective studies should determine if physical activity can slow VF loss in glaucoma and/or if progressive VF loss results in activity restriction. If the former is confirmed, this would mark physical activity as a novel modifiable risk factor for preventing glaucoma damage.”

References

1. Seo JH, Nishida T, Moghimi S, et al. Impact of bodily exercise ranges on visible discipline development in people with glaucoma. J Glaucoma. 2025;34:499-506. DOI: 10.1097/IJG.0000000000002576

2. Lee MJ, Wang J, Friedman DS, Boland MV, De Moraes CG, Ramulu PY. Greater bodily exercise is related to slower visible discipline loss in glaucoma. Ophthalmology. 2018;126:958–64. doi:10.1016/j.ophtha.2018.10.012