Black Sabbath legend Ozzy Osbourne useless at 76 with uncommon Parkinson’s

Rock legend Ozzy Osbourne died on Tuesday at 76 after battling a uncommon type of Parkinson’s illness.

The Black Sabbath lead singer had been open about his situation for the final a number of years, first discussing it throughout an look on ABC’s “Good Morning America” in 2019.

He and spouse Sharon Osbourne revealed the rock star’s prognosis of PRKN-2, a genetic situation sometimes outlined as early-onset Parkinson’s illness that evolves extra slowly.

OZZY OSBOURNE DEAD AT 76

“I’m no good with secrets,” the singer mentioned. “I cannot walk around with it anymore, ’cause it’s like, I’m running out of excuses, you know?”

Osbourne confirmed with GMA that he had a “bad fall” that led to neck surgical procedure and interference along with his nerves.

Singer Ozzy Osbourne performs through the NFL recreation between the Buffalo Bills and the Los Angeles Rams on Sept. 8, 2022, at SoFi Stadium in Inglewood, California. Osbourne died on Tuesday at 76 after battling a uncommon type of Parkinson’s illness. (Brian Rothmuller/Icon Sportswire by way of Getty Images)

The rocker took a while off from performing to deal with his well being issues, however simply weeks earlier than his dying, he took to the stage one final time for Black Sabbath’s “Back to the Beginning” efficiency on July 5 in Birmingham, England.

What causes Parkinson’s?

Dr. Brandon Crawford, a developmental purposeful neurologist in Cedar Park, Texas, and co-founder of the NeuroSolution Center of Austin, famous that Parkinson’s illness can have an effect on everybody in a different way.

The progressive neurodegenerative dysfunction impacts the world of the mind known as the midbrain, which produces the chemical dopamine.

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Dopamine is understood for selling happiness, but it surely additionally motivates the physique to maneuver and suppose.

Only about 10% to fifteen% of Parkinson’s instances are “clearly linked” to genetics, Crawford famous, whereas the bulk is because of a mixture of gentle genetic susceptibility and environmental triggers.

Parkinson’s is a progressive neurodegenerative dysfunction that impacts the world of the mind known as the midbrain, which produces the neurotransmitter dopamine. (iStock)

“Things like toxins, head trauma, sleep disruption or chronic inflammation tip the balance toward disease,” Crawford, who didn’t deal with Osbourne, advised Fox News Digital.

Parkinson’s sufferers sometimes discover a bodily slowing and incapacity to maneuver their physique. Some will first expertise tremors, which Crawford known as a “hallmark sign,” typically starting within the palms.

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The illness may also trigger digestive issues, equivalent to constipation, infected intestine or basic intestinal points. Cognitive decline can also be a “major component” in Parkinson’s improvement, the physician famous.

“Dopamine travels from the midbrain into the frontal lobe, and it gives us our ability to think,” Crawford mentioned. “It gives us a lot of our executive skills. And so that cognitive ability begins to decline.”

Flowers, notes and floral tributes positioned on the Black Sabbath Bridge bench are seen in Birmingham, U.Okay., on July 24, 2025, in reminiscence of Ozzy Osbourne. (Ioannis Alexopoulos/Anadolu by way of Getty Images)

Patients may additionally discover sluggish speech and dysregulated moods, typically exhibiting indicators of melancholy or basic lack of motivation.

“It’s beyond just having tremors or slowed movement,” Crawford mentioned. “This neurodegenerative disease really starts to impact someone’s entire life.”

Disease administration

While there is no such thing as a remedy for Parkinson’s, it may be managed with dopamine agonists (drugs that mimic dopamine) and different stimulants that may stabilize signs for a restricted time.

There could also be “moments of clarity” and higher motion, Crawford mentioned, “but then as those drugs start to wane, everything kind of comes crashing back.”

Ozzy Osbourne and Sharon Osbourne attend the Pre-GRAMMY Gala on January 25, 2020, in Beverly Hills, California. Sharon Osbourne described her husband’s situation throughout a 2019 interview with GMA, explaining how a number of good days are adopted by “a really bad day.” (Alberto E. Rodriguez/Getty Images for The Recording Academy)

Sharon Osbourne described her husband’s situation through the interview with GMA, explaining how a number of good days have been typically adopted by “a really bad day.”

In 2024, throughout an episode of his SiriusXM present “Ozzy Speaks,” with co-host Billy Morrison, the singer shared particulars about stem cell remedies for his situation, which he’d reportedly been receiving for a number of years.

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Kelly Osbourne, Ozzy’s daughter, commented in a 2020 interview with Cells4Life, a U.Okay.-based stem cell financial institution, that her father’s progress after only one remedy was “mind-blowing.”

“He wants to get up. He wants to do things. He wants to be a part of the world again,” she mentioned. “He’s walking better. He’s talking better. His symptoms are lessening. He is building the muscle strength back that he needs.”

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Stem cell remedy for Parkinson’s illness may substitute the dopamine neurons misplaced to degeneration, in accordance with Mass General Brigham. 

The hospital system introduced FDA approval of a Phase 1 medical trial for the remedy in March.

Environmental components

Ozzy Osbourne’s heavy-metal, rock-star life-style almost definitely didn’t assist the event of his situation, in accordance with Crawford.

Circadian disruptions could be a main precursor of Parkinson’s, as staying up late into the evening in synthetic lighting and consuming meals exterior of a standard schedule might be detrimental to the mind.

Ozzy Osbourne’s heavy-metal, rock-star life-style almost definitely didn’t assist the event of his situation, in accordance with a health care provider. (Getty Images)

“When the sun goes down, our retinas, our brain, our entire biology, is not designed to have this high-frequency light stimulus,” he advised Fox News Digital. “Multiple studies show that this type of exposure … can disrupt this circadian biology.”

These components may also alter the microbiome, intestine perform, neurotransmitter manufacturing, liver perform, detox pathways and stem cell migration, and may also promote continual irritation, the physician warned.

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For somebody like Ozzy Osbourne who lived a life-style that almost definitely doesn’t contemplate “natural rhythms,” there could be a increased danger of different situations, like Alzheimer’s or coronary heart illness, in accordance with the knowledgeable.

Other life-style components that would have led to Osbourne’s Parkinson’s prognosis embrace the fixed presence of loud music, substance abuse and head-banging, Crawford talked about.

Ozzy Osbourne performs on stage with Jake E. Lee. Lifestyle components that would have led to Osbourne’s Parkinson’s prognosis embrace the fixed presence of loud music, substance abuse and head-banging, a health care provider mentioned. (Phil Dent/Redferns; Getty Images)

“That’s going to create some repeated head trauma … if you’re going to be up there constantly shaking this brain in your head that’s literally like a bowl full of jelly,” he mentioned. 

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In addition to loud music, research have proven that long-term publicity to heavy metals in a rock star’s surroundings — like mercury, manganese and lead — may result in an elevated danger of Parkinson’s.

“As you’re traveling the world, you’re staying in older venues or using old equipment in a poorly ventilated area,” Crawford mentioned. “All of these things start to add up.”