Male infertility in Indian males linked to way of life decisions and hormonal imbalances

“Lifestyle habits and hormonal imbalances significantly affect the fertility of men.”

BUFFALO, NY — October 10, 2025 — A brand new analysis paper was revealed in Volume 12 of Oncoscience on September 30, 2025, titled “Lifestyle and hormonal factors affecting semen quality and sperm DNA integrity: A cross-sectional study.”

In this research, Saniya Imtiyaz Chamanmalik, Rajendra B. Nerli, and Pankaja Umarane from KLE Academy of Higher Education and Research and Dr. D. Y. Patil Medical College, Hospital and Research Centre found that some way of life decisions and hormone modifications can considerably impression males’s reproductive well being. These findings are particularly essential as male infertility continues to extend in India and world wide.

Infertility impacts one in six {couples} globally, with male-related components contributing to just about half of all instances. This research addressed a significant analysis hole in India by inspecting how modifiable behaviors and hormone ranges affect semen high quality and the genetic integrity of sperm.

The researchers studied 278 Indian males aged 21 to 50. Nearly half of the individuals confirmed irregular semen parameters. While older age didn’t cut back semen quantity or motility, males over 40 had increased ranges of sperm DNA fragmentation, a key marker of genetic injury and diminished fertility potential.

The research discovered sturdy associations between poor way of life decisions and diminished sperm operate. Tobacco and alcohol use considerably lowered sperm depend, motility, and form. Alcohol additionally elevated sperm DNA fragmentation, which might negatively have an effect on embryo growth. Men uncovered to excessive temperatures at work had extra DNA-damaged sperm, displaying the dangerous impression of warmth. Body weight additionally performed a significant position: each underweight and chubby males had decrease semen high quality and better DNA injury in comparison with males of regular weight.

 “Tobacco and alcohol use were strongly associated with reduced sperm concentration, motility, and morphology (p < 0.001).”

In addition to way of life components, the research additionally highlighted the position of hormones in male fertility. Men with low testosterone or excessive prolactin ranges had worse semen profiles. Notably, low ranges of anti-Müllerian hormone (AMH) had been strongly related to increased sperm DNA fragmentation. Since AMH is produced by cells that assist sperm growth, it might function a helpful new marker of sperm well being. Levels of different hormones like FSH and LH remained secure, suggesting that focused hormone testing might enhance fertility evaluation.

This research used the newest World Health Organization pointers for semen evaluation and included superior exams for sperm DNA fragmentation. The outcomes recommend that conventional semen testing might miss essential indicators of fertility. Including way of life analysis and hormone profiling might assist establish reproductive issues earlier and result in more practical therapies.

While the research was restricted to a single heart and didn’t embody long-term follow-up, it supplied priceless details about the rising problem of male infertility in India. The findings assist public well being efforts to advertise more healthy life and common hormone screening. Future analysis might assist decide whether or not way of life modifications or hormone therapies can restore sperm injury and enhance fertility outcomes.

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Correspondence to: Rajendra B. Nerli – [email protected]

Abstract video: 

Keywords: male infertility, way of life threat components, sperm chromatin dispersion take a look at, sperm DNA fragmentation, reproductive hormones

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