Lifestyle, Diet, and Colorectal Cancer Risk According to (Epi)genetic Instability: Current Evidence and Future Directions of Molecular Pathological Epidemiology

TY – JOUR

T1 – Lifestyle, Diet, and Colorectal Cancer Risk According to (Epi)genetic Instability

T2 – Current Evidence and Future Directions of Molecular Pathological Epidemiology

AU – Hughes, Laura A. E.

AU – Simons, Colinda C. J. M.

AU – van den Brandt, Piet A.

AU – van Engeland, Manon

AU – Weijenberg, Matty P.

PY – 2017/12

Y1 – 2017/12

N2 – Purpose of Review In this evaluation, we describe molecular pathological epidemiology (MPE) research from around the globe which have studied food plan and/or way of life components in relation to molecular markers of (epi) genetic pathways in colorectal most cancers (CRC), and discover future views on this realm of analysis. The foremost focus of this evaluation is food plan and way of life components for which there’s proof for an affiliation with CRC as recognized by the World Cancer Research Fund reviews. In addition, we evaluation promising hypotheses, that warrant consideration in future research.Recent Findings Associations between molecular traits of CRC have been revealed in relation to smoking, alcohol consumption; physique mass index (BMI); waist: hip ratio; grownup attained top; bodily exercise; adolescence vitality restriction; dietary acrylamide, fiber, fats, methyl donors, omega 3 fatty acids; meat, together with whole protein, processed meat, and heme iron; and fruit and vegetable consumption.Summary MPE research assist determine the place associations between food plan, way of life, and CRC threat might in any other case be masked and in addition make clear how timing of publicity can affect etiology. Sample measurement is usually a problem, however this can be addressed sooner or later by pooling information.

AB – Purpose of Review In this evaluation, we describe molecular pathological epidemiology (MPE) research from around the globe which have studied food plan and/or way of life components in relation to molecular markers of (epi) genetic pathways in colorectal most cancers (CRC), and discover future views on this realm of analysis. The foremost focus of this evaluation is food plan and way of life components for which there’s proof for an affiliation with CRC as recognized by the World Cancer Research Fund reviews. In addition, we evaluation promising hypotheses, that warrant consideration in future research.Recent Findings Associations between molecular traits of CRC have been revealed in relation to smoking, alcohol consumption; physique mass index (BMI); waist: hip ratio; grownup attained top; bodily exercise; adolescence vitality restriction; dietary acrylamide, fiber, fats, methyl donors, omega 3 fatty acids; meat, together with whole protein, processed meat, and heme iron; and fruit and vegetable consumption.Summary MPE research assist determine the place associations between food plan, way of life, and CRC threat might in any other case be masked and in addition make clear how timing of publicity can affect etiology. Sample measurement is usually a problem, however this can be addressed sooner or later by pooling information.

KW – Colorectal most cancers

KW – Molecular pathological epidemiology

KW – Diet

KW – Lifestyle

KW – Review

KW – ISLAND METHYLATOR PHENOTYPE

KW – SPORADIC COLON CARCINOMAS

KW – KRAS MUTATION STATUS

KW – BODY-MASS INDEX

KW – MICROSATELLITE INSTABILITY

KW – CIGARETTE-SMOKING

KW – PROMOTER METHYLATION

KW – RECTAL-CANCER

KW – APC MUTATIONS

KW – NETHERLANDS COHORT

U2 – 10.1007/s11888-017-0395-0

DO – 10.1007/s11888-017-0395-0

M3 – Article

SN – 1556-3790

VL – 13

SP – 455

EP – 469

JO – Current Colorectal Cancer Reports

JF – Current Colorectal Cancer Reports

IS – 6

ER –