Impact of an interdisciplinary weight reduction and way of life intervention on testosterone and scores for sexual exercise on the FOSQ in males with weight problems and obstructive sleep apnea: secondary analyses of knowledge from the INTERAPNEA randomized trial

dc.contributor.creator Herrera-Quintana, Lourdes  dc.contributor.creator Vázquez-Lorente, Héctor  dc.contributor.creator Ruiz Ruiz, Jonatan  dc.contributor.creator Amaro-Gahete, Francisco J dc.contributor.creator Carneiro-Barrera, Almudena  dc.date.accessioned 2026-09-15T06:22:26Z dc.date.obtainable 2026-09-15T06:22:26Z dc.date.issued 2026-07-10 dc.identifier.quotation Herrera-Quintana L†*, Vázquez-Lorente H†, Jonatan R Ruiz, Amaro-Gahete FJ, Carneiro-Barrera A.. Impact of an interdisciplinary weight reduction and way of life intervention on testosterone and FOSQ-derived sexual exercise in males with weight problems and obstructive sleep apnea: secondary analyses of the INTERAPNEA randomized trial. Maturitas. 2026; 211:109045. doi: 10.1016/j.maturitas.2026.109045. es_ES dc.identifier.uri dc.description.summary Background: Low circulating testosterone and lowered sexual exercise are widespread in males with obstructive sleep
apnea.
Objectives: To consider the impact of an interdisciplinary weight reduction and way of life intervention on circulating
testosterone concentrations and, secondarily, on scores on the intimate relationships and sexual exercise subdomain
of the Functional Outcomes of Sleep Questionnaire (FOSQ).
Methods: Eighty-nine males had been assigned to both common care (n = 49) or an 8-week interdisciplinary intervention
(n = 40). Assessments had been carried out at baseline, on the finish of the intervention (8 weeks), and 6 months postintervention.
Plasma testosterone was measured by chemiluminescence immunoassay. Sexual exercise was
assessed utilizing the intimate relationships and sexual exercise subdomain of the FOSQ. Sleep parameters and physique
weight and composition had been additionally evaluated.
Results: Compared with the management group, larger plasma testosterone concentrations had been noticed within the
intervention group at 8 weeks (between-group distinction 77.6 [95% CI 4.2 to 150.1] ng/dL; p = 0.042) and at 6
months (between-group distinction 90.4 [95% CI 11.7 to 169.0] ng/dL; p = 0.027). Scores on the FOSQ intimate
relationships and sexual exercise subdomain elevated within the intervention group each at 8 weeks (between-group
distinction 1.0 [95% CI 0.5 to 1.5]; p = 0.004) and 6 months (between-group distinction 0.8 [95% CI 0.2 to 1.3]; p
= 0.003) in contrast with controls. Changes in testosterone and FOSQ-derived sexual exercise scores correlated with favorable adjustments in sleep high quality, physique weight and physique composition, significantly from baseline to six months and from 8 weeks to six months (all p <0.05).
Conclusions:
In males with obese or weight problems and average to extreme obstructive sleep apnea, an interdisci
plinary weight reduction and way of life intervention elevated circulating testosterone concentrations in contrast with common care. Improvements had been additionally noticed in scores on the intimate relationships and sexual exercise
area of the FOSQ; nevertheless, these findings needs to be thought of exploratory as a result of this subdomain doesn’t assess erectile operate, libido, hypogonadal signs, or validated multidimensional domains of male sexual operate. Further research utilizing complete endocrine profiling and validated male sexual operate
struments are warranted. es_ES dc.language.iso eng es_ES dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional * dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ * dc.topic Obstructive sleep apnea es_ES dc.topic Testosterone es_ES dc.topic Sexual exercise es_ES dc.topic Androgenic operate es_ES dc.topic Obesity Weight loss es_ES dc.title Impact of an interdisciplinary weight reduction and way of life intervention on testosterone and scores for sexual exercise on the FOSQ in males with weight problems and obstructive sleep apnea: secondary analyses of knowledge from the INTERAPNEA randomized trial es_ES dc.kind journal article es_ES dc.rights.accessRights embargoed entry es_ES dc.identifier.doi 10.1016/j.maturitas.2026.109045