Transcriptomics, life-style, and autoimmune thyroiditis: an built-in affiliation research

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<< /Author (Chun-Hu Li) /CreationDate (D:20260620091901+08’00’) /Keywords (autoimmune thyroiditis; immune-related genes; life-style habits; RNA sequencing; transcriptomic danger rating) /ModDate (D:20260620091901+08’00’) /Subject (Li C-H, Liu Y-H, Yue Z-Y, Zeng X-Ok, Zhang Z-X, Li X, Liu Y-H, Li Y-H, Zhao T and Liu P (2026) Transcriptomics, life-style, and autoimmune thyroiditis: an built-in affiliation research. Front. Immunol. 17:1853447. doi: 10.3389/fimmu.2026.1853447) /Title (Transcriptomics, life-style, and autoimmune thyroiditis: an built-in affiliation research) >>
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autoimmune thyroiditis; immune-related genes; life-style habits; RNA sequencing; transcriptomic danger rating


2026-06-20T09:19:01+08:00
2026-06-20T09:19:01+08:00
2026-06-20T09:19:01+08:00


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<< /A 37 0 R /Alt (Flowchart illustrating a analysis course of for IRDEG screening, validation, and affiliation evaluation, detailing dataset sources, differential evaluation, regression strategies, gene discovery, multi-province validation, RSR rating calculation, evaluation steps, and life-style issue integration.) /Ok 0 /P 8 0 R /Pg 28 0 R /S /Figure /T () >>
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<< /A 38 0 R /Alt (Panel A exhibits a PCA scatterplot earlier than batch correction with two clusters, pink circles and cyan triangles, separated alongside principal parts. Panel B exhibits improved overlap between the identical clusters after batch correction. Panel C is a volcano plot for the GEO dataset illustrating gene expression adjustments; blue, pink, and grey dots point out downregulated, upregulated, and non-differential genes respectively. Panel D is a volcano plot for the Anhui dataset with comparable gene distribution coloration coding. Panel E is a three-set Venn diagram evaluating Anhui, GEO, and ImmPort datasets, with an intersection of 54 shared parts.) /Ok 0 /P 8 0 R /Pg 29 0 R /S /Figure /T () >>
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<< /A 39 0 R /Alt (Panel A shows a line plot displaying LASSO regression coefficients versus log-transformed lambda values, with a number of coloured strains converging towards zero. Panel B presents a line graph of binomial deviance in opposition to log-transformed lambda values for LASSO, that includes a pink curve with error bars and two vertical dashed strains marking optimum lambda choices. Panel C is a horizontal bar chart displaying the imply SHAP values for IFI16, CASP4, and LY96, rating their relative significance. Panel D comprises a receiver working attribute curve in blue, displaying excessive mannequin efficiency with space beneath the curve equal to zero level 9 two zero and confidence interval of zero level eight two 5 to 1.) /Ok 0 /P 8 0 R /Pg 30 0 R /S /Figure /T () >>
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<< /A 40 0 R /Alt (Six grouped bar charts with error bars examine gene expression (IFI16, CASP4, LY96, CCR1, IL1B, BKT) between No AIT (blue) and AIT (orange) teams. Significant variations are noticed for IFI16, CASP4, and BKT, with corresponding statistical values and p-values displayed above every panel.) /Ok 0 /P 8 0 R /Pg 32 0 R /S /Figure /T () >>
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