Effectiveness of eHealth life-style interventions on administration of metabolic dysfunction-associated steatotic liver illness: a scientific assessment and meta-analysis

Abstract

eHealth life-style interventions have emerged as promising administration methods for metabolic dysfunction-associated steatotic liver illness (MASLD). Our assessment aimed to synthesize the newest proof to judge the effectiveness of eHealth life-style interventions on medical and behavioral outcomes in adults with MASLD. Twelve databases (Medline, Web of Science Core Collection, Embase, Cochrane Central Register of Controlled Trials, ProQuest Health & Medical Collection, CINAHL Complete, Academic Search Complete, Scopus, Emerald, China National Knowledge Infrastructure, Wanfang Data, and VIP Database) have been searched from inception to April 2, 2025. Thirteen randomized managed trials and fifteen quasi-experimental trials comprising 2579 grownup sufferers with MASLD have been included. Seven intervention parts have been recognized: objective setting, well being schooling, session, self- and device-monitoring, suggestions, affected person reminders, and social assist. Meta-analysis of randomized managed trials demonstrated that eHealth life-style interventions have been considerably superior to plain care in decreasing weight, physique mass index, waist circumference, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transferase ranges, and bettering MASLD standing. Improvements in self-management, dietary adherence, bodily exercise, train, and high quality of life have been additionally noticed. Our findings counsel that ehealth intervention is a more sensible choice for the sufferers with MASLD to realize exact and scalable administration. PROSPERO CRD420251001470.

Trial registration

PROSPERO CRD420251001470; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251001470.