Human whole-blood NAD+ ranges don’t fluctuate with age or life-style interventions

This web page was created programmatically, to learn the article in its unique location you possibly can go to the hyperlink bellow:
https://www.nature.com/articles/s42255-026-01537-5
and if you wish to take away this text from our web site please contact us


  • Janssens, G. E., Houtkooper, R. H. & Hoeks, J. NAD+ to evaluate well being in getting old people. Aging 14, 5962–5963 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vinten, Ok. T. et al. NAD+ precursor supplementation in human ageing: scientific proof and challenges. Nat. Metab. 7, 1974–1990 (2025).

    Article 
    PubMed 

    Google Scholar
     

  • Zhang, J. et al. Emerging methods, purposes and challenges of concentrating on NAD+ within the clinic. Nat. Aging 5, 1704–1731 (2025).

    Article 
    PubMed 

    Google Scholar
     

  • Aman, Y., Qiu, Y., Tao, J. & Fang, E. F. Therapeutic potential of boosting NAD+ in getting old and age-related illnesses. Transl. Med. Aging 2, 30–37 (2018).

    Article 

    Google Scholar
     

  • Janssens, G. E. et al. Healthy getting old and muscle operate are positively related to NAD+ abundance in people. Nat. Aging 2, 254–263 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Houtkooper, R. H. & Auwerx, J. Exploring the therapeutic house round NAD+. J. Cell Biol. 199, 205–209 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chaleckis, R., Murakami, I., Takada, J., Kondoh, H. & Yanagida, M. Individual variability in human blood metabolites identifies age-related variations. Proc. Natl Acad. Sci. USA 113, 4252–4259 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang, P. et al. Fingerstick blood assay maps real-world NAD+ disparity throughout gender and age. Aging Cell 22, e13965 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang, F. et al. Association of human entire blood NAD+ contents with getting old. Front. Endocrinol. (Lausanne) 13, 829658 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Euro, L. et al. Dynamics of blood NAD and glutathione in well being, illness, getting old and underneath NAD-booster therapy. Preprint at bioRxiv (2025).

  • Breton, M. et al. Blood NAD ranges are lowered in very previous sufferers hospitalized for coronary heart failure. Exp. Gerontol. 139, 111051 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Janssens, G. E. et al. A metabolomic signature of decelerated physiological getting old in human plasma. GeroScience 45, 3147–3164 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schomakers, B. V. et al. Polar metabolomics in human muscle biopsies utilizing a liquid–liquid extraction and full-scan LC–MS. STAR Protoc. 3, 101302 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Giner, M. P. et al. A technique to watch the NAD+ metabolome—from mechanistic to scientific purposes. Int. J. Mol. Sci. 22, 10598 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lapatto, H. A. Ok. et al. Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite tv for pc cell differentiation, and intestine microbiota in a twin examine. Sci. Adv. 9, eadd5163 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Noguera-Navarro, C. et al. Multi-omic evaluation and platelet operate distinguish therapy responses to hydroxytyrosol in cardiovascular danger. Food Funct. 16, 5928–5948 (2025).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • van Hattum, J. C. et al. ELITE: rationale and design of a longitudinal elite athlete, excessive cardiovascular phenotyping, potential cohort examine. BMJ Open Sport Exerc. Med. 9, e001505 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schoenmaker, M. et al. Evidence of genetic enrichment for distinctive survival utilizing a household method: the Leiden Longevity Study. Eur. J. Hum. Genet. 14, 79–84 (2006).

    Article 
    PubMed 

    Google Scholar
     

  • Westendorp, R. G. J. et al. Nonagenarian siblings and their offspring show decrease danger of mortality and morbidity than sporadic nonagenarians: the Leiden Longevity Study. J. Am. Geriatr. Soc. 57, 1634–1637 (2009).

    Article 
    PubMed 

    Google Scholar
     

  • Benali, M. et al. Efficacy of progressive resistance coaching intensities and ample dietary protein consumption for community-dwelling frail older adults (TEAMS examine), protocol for a randomised managed trial. BMC Geriatr. 25, 609 (2025).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Olaso-Gonzalez, G. & Millan-Domingo, F. A multidomain life-style intervention is related to improved practical trajectories and favorable modifications in epigenetic getting old markers in frail older adults: a randomized managed trial. Aging Cell. 25, e70376 (2026).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jacobson, E. L. & Jacobson, M. Ok. A biomarker for the evaluation of niacin nutriture as a possible preventive think about carcinogenesis. J. Intern. Med. 233, 59–62 (1993).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Funaro, A. et al. CD157 is a crucial mediator of neutrophil adhesion and migration. Blood 104, 4269–4278 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Franco, L. et al. Self-aggregation of the transmembrane glycoprotein CD38 purified from human erythrocytes. Biochem. Biophys. Res. Commun. 202, 1710–1715 (1994).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yoshino, J. & Imai, S.-I. Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography. Methods Mol. Biol. 1077, 203–215 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim, H.-Y. Statistical notes for scientific researchers: Sample measurement calculation 1. Comparison of two unbiased pattern means. Restor. Dent. Endod. 41, 74–78 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Usami, S. Generalized pattern measurement willpower formulation for experimental analysis with hierarchical information. Behav. Res. Methods 46, 346–356 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • McKay, A. Ok. A. et al. Defining coaching and efficiency caliber: a participant classification framework. Int. J. Sports Physiol. Perform. 17, 317–331 (2021).

    Article 

    Google Scholar
     

  • Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E. & Storey, J. D. The sva package deal for eradicating batch results and different undesirable variation in high-throughput experiments. Bioinformatics 28, 882–883 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wickham, H. ggplot2: Elegant Graphics for Data Analysis (Springer, 2016).

  • Wickham, H., François, R., Henry, L. & Müller, Ok. dplyr: A grammar of information manipulation. R package deal model 1.1.4. CRAN (2021).

  • Wickham, H. & Henry, L. tidyr: Tidy messy information. R package deal model 1.3.1. CRAN (2020).

  • Kassambara, A. ggpubr: ‘ggplot2’ Based publication prepared plots. R package deal model 4.0.1. CRAN (2018).

  • Auguie, B. & Antonov, A. gridExtra: Miscellaneous features for “grid” graphics. R package deal model 2.3. CRAN (2017).

  • Slowikowski, Ok. et al. ggrepel: Automatically place non-overlapping textual content labels with ‘ggplot2’. R package deal model 0.9.6. CRAN (2021).

  • Rohart, F., Gautier, B., Singh, A. & Cao, Ok.-A. L. mixOmics: An R package deal for ‘omics function choice and a number of information integration. PLoS Comput. Biol. 13, e1005752 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pedersen, T. L. ggforce: Accelerating ‘ggplot2’. R package deal model 0.5.0. CRAN (2019).


  • This web page was created programmatically, to learn the article in its unique location you possibly can go to the hyperlink bellow:
    https://www.nature.com/articles/s42255-026-01537-5
    and if you wish to take away this text from our web site please contact us