Gender-related facilitators and limitations in implementing mixed life-style interventions for people with knee osteoarthritis and chubby or weight problems: views of healthcare professionals and sufferers in a qualitative examine

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STRENGTHS AND LIMITATIONS OF THIS STUDY

  • The views of each healthcare professionals and people with knee osteoarthritis and chubby or weight problems concerned in a mixed life-style intervention had been recognized.

  • Purposive sampling was used to incorporate a various pattern when it comes to age, intercourse, socioeconomic standing and attendance standing to a mixed life-style intervention.

  • Only Dutch folks had been interviewed and variety in gender and well being literacy was restricted, limiting generalisability.

  • The danger of recall bias was minimised by conducting interviews throughout or shortly after participation in a mixed life-style intervention.

Introduction

Knee osteoarthritis (OA) is a continual and progressive joint dysfunction, resulting in ache, stiffness and decreased bodily perform.1 It is likely one of the main causes of incapacity worldwide, particularly amongst older adults.2 In the Netherlands, OA is predicted to develop into probably the most prevalent continual illness by 2040, primarily because of the ageing inhabitants and the rising prevalence of chubby and weight problems.3 A excessive physique mass index (BMI) just isn’t solely a serious danger issue for the event and development of knee OA, but additionally an important modifiable issue within the therapy of knee OA.4 Therefore, early interventions aimed toward physique weight reduction, resembling life-style interventions, are important to sluggish the development of knee OA, enhance high quality of life and scale back stress on healthcare programs.5

Combined life-style interventions (CLIs) have proven promise for people with knee OA who’re chubby and overweight.6 These interventions combine bodily exercise, wholesome vitamin and behavioural change methods to assist physique weight reduction and a more healthy life-style.7 However, their effectiveness relies upon not solely on scientific outcomes but additionally on profitable referral and implementation by healthcare professionals (HCPs), in addition to acceptance and adherence by people with knee OA. In major care, HCPs resembling normal practitioners (GPs) and bodily therapists recognise the significance of life-style interventions, however reported sensible and organisational challenges.8 9 Furthermore, folks’s particular person circumstances, together with gender-related social roles, obligations and expectations, decide whether or not a programme meets their wants and whether or not they can profit from it.10

Gender-related elements could affect the implementation, uptake and adherence to CLIs in people with knee OA and chubby or weight problems.11 HCPs could have unconscious biases relating to intercourse and gender,12 which may affect healthcare given to sufferers.13 14 Hence, intercourse and gender analyses might help to disclose such inequalities and develop methods to advertise extra equitable healthcare.11–13 It is due to this fact important to guage how HCPs understand and work together with folks of various genders,15 as these could affect referral patterns, engagement of people and the probability of adherence to a CLI. Current insights into this gender-related interplay within the CLI are restricted, whereas understanding it could actually strengthen the patient-HCP relationship, supporting accessibility and long-term adherence to a CLI.

Although the CLI appears to fulfill the wants of people with chubby and weight problems,16 women and men would possibly differ of their preferences and motivations for a wholesome life-style. Previous analysis has proven intercourse variations in motivations, with males extra more likely to be motivated by efficiency and health objectives, whereas girls usually tend to be motivated by weight administration and bettering well-being and well being.17 Additionally, males usually understand weight-reduction plan as female.18 19 Although each bodily exercise and wholesome vitamin are built-in in CLIs, in follow the emphasis appears to be extra on wholesome vitamin. This imbalance is mirrored within the underrepresentation of males in life-style trials and the truth that roughly 70% of CLI members within the Netherlands are girls.20 21 Difference in preferences, motivations, perceptions and experiences within the CLI can all affect each participation in and adherence to a CLI. However, the main focus has primarily been on the content material of life-style interventions, whereas variations in particular person circumstances, motivations and communication preferences have to be additional investigated.

Gaining insights into gender-related facilitators and limitations from a number of views facilitates the implementation and acceptance of the CLI in each women and men. Therefore, this examine goals to establish gender-related facilitators and limitations to the implementation of CLIs for HCPs who referred or delivered them. To complement the findings of HCPs, gender-related facilitators and limitations to the uptake and adherence of CLIs had been investigated in people with early-stage knee OA and chubby or weight problems.

Methods

This examine was reported in accordance with the Standards for Reporting Qualitative Research and Sex and Gender Equity in Research.22 23 This qualitative examine is an extension of the interview examine carried out as a part of the Lifestyle Intervention Trial for Early-stage knee OA (LITE) examine.24 The LITE examine was a multi-centre pragmatic randomised managed trial wherein members within the intervention group adopted the 2-year ‘Beweegkuur’ CLI.25 A complete of 218 people participated within the LITE examine, of whom 109 had been allotted to the CLI. Participants within the LITE examine had been between 45 and 70 years of age, clinically identified knee OA in accordance with the National Institute for Health and Care Excellence (NICE) guideline26 had a BMI of ≥25 kg/m2 or greater, and consulted their GP for the primary time with knee complaints within the earlier 24 months.

We outlined intercourse as ‘a set of biological attributes of humans, including physical features, chromosomes, gene expression, hormones and anatomy” and gender as “the socially constructed roles, behaviours, expressions and identities of women, men, and gender-diverse people’.23

Study design

The design of this examine is qualitative, following an interpretivist strategy, to realize insights into views of HCPs who referred or delivered a CLI and people with knee OA and chubby or weight problems who participated in a CLI. Throughout the strategies and outcomes part of this manuscript, ‘HCPs’ and ‘participants’ refer to those respective teams. Semi-structured interviews had been carried out with HCPs to establish gender-related limitations and facilitators for the design and implementation of the approach to life intervention, and with people with knee OA to establish gender-related limitations and facilitators to the uptake and adherence of the CLI.

The interview guides and coding timber had been guided by the up to date Consolidated Framework for Implementation Research (CFIR).27 This framework is well-recognised within the implementation science subject. The up to date CFIR consists of 5 domains: innovation, outer setting, inside setting, people and implementation course of. For this examine, the interview guides had been expanded with further subjects that particularly addressed gender-related elements. For HCPs, the extra subjects had been affected person elements (eg, gender identification of affected person, psychosocial), supplier elements (eg, gender identification of HCP) and provider-patient relationship (eg, communication and expectations). For members, the extra subjects had been healthcare-related elements (eg, gender identification of HCP, relationship and communication with HCP, expectation of HCP) and environmental elements (eg, social community, work, family actions and caretaking).

Recruitment and sampling

HCPs (mixture of GPs, life-style coaches and train professionals) who had been concerned within the LITE examine and referred or supplied care to not less than two LITE members had been invited for the interviews. In addition, LITE members allotted to the intervention arm had been invited to take part within the interviews. Purposive sampling was used to recruit GPs and members throughout totally different normal practices, with a variety of ages, sexes and variety of CLI periods attended (eg, LITE members who’ve accomplished the CLI or dropped out early).

Furthermore, to realize insights into experiences with totally different CLI programmes, interviews had been carried out with HCPs and members who weren’t concerned within the LITE examine however had been collaborating in CLI programmes aside from the ‘Beweegkuur’. These members had been recruited by way of LinkedIn and the analysis staff’s community.

Data assortment

Prior to the beginning of the interview, written knowledgeable consent was obtained from HCPs and members. Between December 2023 and May 2024, the semi-structured interviews had been carried out in Dutch, both on-line or in individual on the division of General Practice in Erasmus MC when on-line participation was not potential. Two members of the analysis staff (NEJ and PG) carried out the interviews with the HCPs and members. Neither of them had a scientific relationship with the members, and one in all them (NEJ) knew the members from the analysis visits. After the primary interview, minor adaptions in wording of questions had been made to make clear the questions within the interview information. To guarantee methodological consistency, the primary two interviews had been carried out by each researchers collectively. The remaining interviews had been carried out by one researcher. Prompts had been supplied to HCPs and members once they had difficulties with giving their very own examples. The interviews lasted roughly 45–60 min. All had been video recorded by way of Microsoft Teams if carried out on-line or audio recorded by way of a voice recorder if carried out in individual. All interviews had been transcribed verbatim. Data saturation was thought-about reached when new interviews didn’t give any further insights.

Demographic knowledge had been collected at the start of the interview from HCPs and by way of a web-based questionnaire from members as commonplace process of the LITE examine. Sex and gender identification had been self-reported utilizing the next questions, translated from Dutch: ‘What was your sex at birth?’ and ‘What is your gender identity?’, respectively. In addition, gender-related knowledge had been collected completely from members concerned within the LITE examine (n=218) utilizing the Dutch model of the Stanford Gender-related Variable for Health Research questionnaire.28 29 These knowledge weren’t obtained from members who weren’t concerned within the LITE examine and HCPs. This questionnaire accommodates questions on seven gender-related variables: work pressure, social assist, danger taking, independence, emotional intelligence, discrimination and caregiver pressure.

Data evaluation

Thematic evaluation, combining inductive and deductive approaches, was carried out utilizing MAXQDA 2018 (VERBI Software GmbH, Berlin, Germany). First, two researchers (NEJ and PG) independently coded two interview transcripts inductively to develop preliminary codes. Then, the codes had been linked to one of many 5 CFIR domains and organised into separate coding timber for HCPs and members reflecting each views. Following a dialogue with a 3rd researcher (DS) in regards to the coding timber, the coding timber had been revised, and one other interview transcript was coded utilizing the revised coding timber. After 75% inter-rater reliability was achieved between two researchers (NEJ and PG), primarily based on code definition and overlap in themes, one researcher (PG) coded the remaining transcripts.

For the aim of this examine, we made separate coding timber for every gender identification. If demographic knowledge on self-reported gender identification had been lacking, we assumed the gender identification of members on the unspecified query ‘What is your sex/gender’ on the baseline of the LITE examine. Themes and subthemes had been created primarily based on associated codes, and discrepancies had been resolved by way of a consensus assembly with the analysis staff (CMH, NEJ, PG, DS, PPLB and MvM). For HCPs, we’ve got solely targeted on the outer setting area of CFIR, particularly on the affect of gender. For members, we targeted on the domains of outer setting, inside setting and people from CFIR. The themes and subthemes had been linked to the above-mentioned domains. Quotes introduced for every subtheme are translated from Dutch to English.

Credibility was ensured by way of triangulation, as we concerned each HCPs and CLI members to seize various views. Dependability was supported by a scientific coding course of and evaluation of inter-rater reliability. Coding choices and thematic interpretations had been refined by way of discussions inside the researcher staff. Confirmability was ensured by linking the themes and subthemes to the CFIR framework. The quotes additional reveal that the findings are supported by the information.

Patient and public involvement

Patient involvement was promoted by way of the Artrose Gezond (ie, Healthy with OA) platform, which is coordinated by Erasmus MC. Input from sufferers and HCPs was included into the event of interview guides. In addition, sufferers contributed to the analysis design and interpretation of the information by way of workshops. The findings had been additionally mentioned with GPs and life-style coaches to collect skilled insights and discover the implications for scientific follow.

Results

In complete, 16 HCPs and 23 people with knee OA and chubby or weight problems had been interviewed. HCPs had been a mixture of GPs (n=7), life-style coaches (n=8) and an train skilled (n=1), recognized themselves as girls (50%) or males (25%) (25% lacking) and had a median age of 39 years (vary: 31–59). Participants recognized themselves as girls (70%) or males (30%), had been largely adequately well being literate, had a mixture of socioeconomic statuses, a median age of 56 years (vary: 46–71) and 87% participated within the ‘Beweegkuur’ CLI and 13% in one other CLI (table 1). As no HCPs and members recognized themselves as non-binary or genderqueer, the outcomes had been restricted to the gender identities of man and lady.

Table 1

Characteristics of people with knee OA and chubby or weight problems

The definitions of the recognized subthemes within the outer setting area of CFIR inside the theme ‘Influence of gender’ are supplied in table 2. Quotes supporting the findings relating to the facilitators and limitations are introduced individually for women and men for every subtheme in online supplemental table S1 (Q… references to the corresponding quotes (HCP, healthcare skilled; W, lady; M, man).

Table 2

CFIR area, theme and subthemes for the implementation of the CLI

Subtheme: participant–HCP relationship

HCPs perceived that girls are usually extra social, open and honest (Q1, HCP13) and usually tend to comply with the CLI than males (Q2, HCP04). In normal, HCPs noticed bigger participation of ladies within the CLI. Participants who recognized themselves as lady talked about that modifications in HCPs or no match with HCPs could hinder the openness, as a result of they should rebuild belief with an HCP (Q3, W07 and This autumn, W12). Furthermore, some girls choose to debate subjects resembling weight reduction and menopause with a feminine HCP (Q5, W03), however greater than half of them don’t have any choice for the gender of an HCP. HCPs skilled that males are much less open and discover it difficult to share private data and their true emotions (Q6, HCP11 and Q7, HCP13). Based on particular person experiences, one participant recognized as a person noticed that the presence of ladies in CLI group periods led to extra interplay, and one other man appreciated the empathy that feminine HCPs usually confirmed (Q8, M06). Most males don’t have any choice for the gender of an HCP.

Regarding communication, each women and men skilled that the progress of the CLI might be hampered by totally different opinions of HCPs (Q9, W05), poor communication or failure of HCPs to maintain appointments (Q10, M04).

Subtheme: work-life steadiness

HCPs talked about that males have much less time to take part within the CLI as a result of they’re extra more likely to work full-time than girls (Q11, HCP08 and Q12, HCP16). Both members who recognized themselves as man or lady skilled that the CLI may very well be adopted alongside work (Q13, W06 and Q14, M06). On the opposite hand, each perceived irregular working hours, stress or bodily calls for at work as a barrier to participating in sports activities and altering their eating regimen (Q15, W11 and Q16, M02). In addition, some girls talked about that scheduling appointments was typically difficult as a result of they conflicted with working hours (Q17, W05). Responses to the Gender-related Variable for Health Research (GVHR) questionnaire on work pressure align with the interview responses from each women and men relating to work-life steadiness, exhibiting similarities in experiences of labor pressure between women and men (figure 1).

Figure 1Figure 1
Figure 1

Responses to the Stanford Gender-related Variable for Health Research (GVHR) questionnaire from 163 LITE members who recognized themselves as man or lady. LITE, Lifestyle Intervention Trial for Early-stage knee.

Most women and men didn’t appear to have conventional gender roles at residence and appear to have an equal division of labour at residence (Q18, M06). However, some did have conventional gender roles, with girls primarily caring for his or her residence and kids whereas males labored extra (Q19, W02). Regarding care obligations, some women and men cared for his or her grandchildren a couple of times per week (Q20, M04). In addition, one man had care duties for his companion as a result of she had well being issues. Some girls had been casual carers for his or her dad and mom (Q21, W10), and one lady needed to take care of her little one with an mental incapacity. Traditional gender roles and care obligations could have an effect on the flexibility to take part in CLI programmes, because of time constraints and restricted flexibility in managing each day obligations. Responses to the GVHR questionnaire on caregiver pressure confirmed barely greater ranges of caregiver pressure in girls in contrast with males, though the distinction was small (figure 1).

Subtheme: behavioural elements

An HCP talked about that males are extra direct and fewer complicated, for instance, they simply comply with recommendation with out asking why (Q22, HCP16), whereas girls have extra excuses and present extra resistance to the CLI (Q23, HCP16). However, different HCPs perceived extra resistance to the CLI in males than in girls (Q24, HCP05). Both members who recognized themselves as man or lady perceived limitations of self-discipline. Both appear to know what they need to do to eat more healthy or begin exercising however appear to fail to regulate their behaviour (Q25, M06, Q26, M03 and Q27, W09). Additionally, an HCP talked about that girls have a tendency to hunt different therapies, resembling Saxenda, extra shortly (Q28, HCP09).

HCPs talked about that girls usually put themselves final as a result of they’ve lots on their minds and are busier with others (Q29, HCP16). This was skilled by girls, dealing with stress because of each private causes and exterior elements, resembling diseases and deaths of household and mates, which typically even made them give up the CLI (Q30, W03).

Subtheme: social setting assist

HCPs famous that girls typically lack social assist from their companions and kids, who’re unwilling to adapt and due to this fact fail to create a supportive setting (Q31, HCP15). This was not particularly talked about by members who recognized themselves as lady. Both women and men did point out that social assist contributed to wholesome consuming habits, sports activities follow and participation in life-style interventions (Q32, M06 and Q33, W09). Men referred solely to social assist from their companions, whereas girls moreover referred to social assist from household and companions. Responses to the GVHR questionnaire on social assist point out nearly comparable ranges of perceived social assist between women and men, with barely greater scores in males (figure 1).

No variations between women and men

Besides the variations talked about by HCPs, six HCPs famous that they assume that there isn’t a distinction between women and men within the implementation, uptake and adherence to the CLI. HCPs talked about that it is extremely private, and that age performs a task, with older folks typically being extra receptive to the CLI in contrast with youthful folks.

GVHR questionnaire outcomes

A complete of 163 LITE members accomplished the GVHR questionnaire. Figure 1 exhibits the gender-related variables stratified in accordance with members who recognized themselves as man or lady. Men skilled greater work pressure, had extra social assist and had been extra prepared to take dangers. Women valued independence extra, had larger emotional intelligence, felt extra discrimination and skilled greater caregiver pressure. However, variations between genders had been typically small.

Discussion

The examine intention was to establish gender-related facilitators and limitations to the implementation of CLIs for HCPs who referred or delivered a CLI. To complement the findings of HCPs, gender-related facilitators and limitations to the uptake and adherence of CLIs had been recognized in people with early-stage knee OA and chubby or weight problems who participated in a CLI. Since not one of the members recognized as non-binary or genderqueer, the outcomes had been restricted to women and men. In normal, HCPs perceived resistance to CLIs from members who recognized themselves as both man or lady. They perceived that girls had been extra open and obtainable to take part in CLIs, tended to prioritise others over themselves and sometimes lacked familial assist in contrast with males. While each women and men talked about social assist of their setting as a key facilitator. In addition, limitations for each women and men included conflicting HCP recommendation, work stress, caregiving duties and lack of self-discipline. Furthermore, girls valued belief, most popular feminine HCPs and struggled with self-prioritisation. Men had been motivated by feminine HCPs and members because of their empathy and interplay. There had been additionally HCPs who talked about no distinction between women and men.

Individuals who recognized themselves as lady with knee OA and chubby or weight problems worth a private reference to their HCP, indicating a choice for emotional empathy—feeling one other individual’s feelings.30 31 Furthermore, HCPs perceived girls as extra social, open and more likely to comply with the CLI, whereas males had been seen as extra reserved, particularly in sharing private data. In line with the expertise from HCPs and members, emotional empathy is greater in girls than in males.30 31 However, variations in cognitive empathy—understanding one other individual’s feelings—between women and men are much less clear.31 Higher empathy in girls is linked to more practical and empathetic communication kinds, which may enhance social interactions.32 Awareness amongst HCPs of particular person variations in emotional empathy might help construct stronger relationships with members and should enhance their uptake of and adherence to a CLI.

Although most interviewed members didn’t point out conventional gender roles, some girls did point out that their husbands typically labored extra, whereas they themselves took on extra accountability for his or her youngsters and family duties. In addition, each women and men talked about having casual caregiver duties. Both conventional gender roles at residence and casual caregiver duties contribute to greater stress and emotional exhaustion,33 which can have an effect on participation in a CLI. Daily conversations about work, family and care duties can result in a extra equal and satisfying division of labour, which may scale back stress.34 An imbalance between work, caring and family duties can result in stress in each women and men, making it important to deal with in CLIs. Therefore, understanding members’ stressors resembling their roles at residence and their obligations as carers, and incorporating these into CLI periods can enhance engagement with a CLI.

HCPs perceived resistance from people who recognized themselves as man or lady with knee OA and chubby or weight problems. Participants, nevertheless, famous that though they meant to alter their behaviour, they skilled difficulties in doing so. This hole between having the intention to alter behaviour and truly altering behaviour is named the intention-behaviour hole.35 The proof for gender variations within the intention-behaviour hole stays inconclusive; some research report that males usually tend to translate intentions into motion, whereas different research discover the alternative sample.36 Previous analysis means that perceived social assist, intention, planning and self-regulation play key roles in bridging the intention-behaviour hole.37

Of these elements, social setting assist was talked about by each women and men in our examine as a key facilitator within the uptake of more healthy consuming habits and participation in train and life-style interventions. HCPs noticed a scarcity of social assist amongst girls, which is in line with the findings of a earlier qualitative examine on adherence to a dietary life-style intervention in folks with metabolic syndrome.38 However, people who recognized themselves as girls didn’t report a scarcity of social assist. Men talked about that they solely obtained social assist from their companions, whereas girls additionally talked about they obtained assist from household and mates. This is in step with earlier analysis exhibiting that males primarily obtained non-work-related social assist from their spouses, whereas girls rely extra on relations and mates.39 Sources of social assist seem to fluctuate amongst people, however normally, social assist is related to optimistic well being outcomes.40 It is due to this fact essential that HCPs focus on the social assist in members’ environments and its implications in the course of the CLI periods.41

This qualitative examine is the primary to establish gender-related facilitators and limitations within the implementation, uptake and adherence to CLIs. This is related given the rising recognition of gender variations in OA healthcare.15 A energy of this examine was the inclusion of views of each HCPs and people with knee OA and chubby or weight problems concerned in a CLI. Additionally, we included a various pattern when it comes to age, intercourse, socioeconomic standing and CLI attendance standing because of purposive sampling. However, a limitation was the generalisability as a result of we solely interviewed Dutch folks and the range in gender identities and well being literacy was restricted. Furthermore, we included comparatively older members (median age 56 years), which can have influenced the range in gender identities and views on gender, as generational variations usually decide how people understand and take care of these ideas.42 Future analysis would profit from larger range in gender identities, well being literacy and a broader age vary to advertise extra inclusive and equitable healthcare that higher meets the wants of sufferers. Another limitation is the dearth of views from people who didn’t take part in a CLI, which may present perception into limitations to beginning a CLI. Although interviews could introduce a danger of recall bias, conducting them throughout or shortly after CLI participation helped to minimise this danger.

HCPs and people with knee OA and chubby or weight problems had been totally on the identical web page when it comes to facilitators and limitations in people who recognized themselves as both man or lady, however there have been additionally some variations between their perceptions. Therefore, it is crucial to not stigmatise however to take a person strategy when referring or delivering a CLI. Furthermore, incorporating gender-related facilitators and limitations or not less than addressing the subthemes discovered within the current examine (ie. participant–HCP relationship, work-life steadiness, behavioural elements and social setting assist) could enhance the connection between participant and HCP, doubtlessly making a participant extra prepared to stick to the CLI. Not all of those facilitators and limitations might be instantly utilized or modified inside the design and implementation of CLIs. Nevertheless, they might doubtlessly be addressed and included into the content material of CLI periods. Whether these gender-related facilitators and limitations in CLIs might be addressed within the design or implementation of CLIs must be investigated in future implementation analysis. Subsequently, this will enhance adherence to a CLI, which can lead to a larger behavioural change amongst members.

While the intention of a CLI is weight reduction, the methods to realize this will fluctuate. Previous analysis has proven gender variations within the motivational elements for bodily exercise. Women usually tend to be motivated by dropping or managing weight and social elements (ie, along with friends and different girls), whereas males usually tend to be motivated by expert, vigorous and aggressive bodily exercise.43 In addition, women and men differ of their well being beliefs about which meals are thought-about wholesome, which influences their dietary behaviour.44 45 Due to gender variations in motivations and well being beliefs, people could profit from several types of assist throughout CLI participation. Therefore, future analysis ought to examine whether or not incorporating these preferences right into a CLI can enhance adherence to and effectiveness of a CLI throughout totally different genders.

Gender-related facilitators and limitations to the implementation and acceptance of the CLI had been recognized. The design and implementation of the CLI may benefit from incorporating gender variations in communication and interplay preferences, motivation for bodily exercise and health-related dietary beliefs. In addition, incorporating insights into work-life steadiness and social setting assist could enhance its long-term efficacy in people with knee OA and chubby or weight problems.

Data availability assertion

Data can be found upon affordable request.

Ethics statements

Patient consent for publication

Ethics approval

All examine procedures had been in accordance with the Declaration of Helsinki. The LITE examine was authorised by the Medical Ethics Review Committee of Erasmus University Medical Centre (registration quantity: 2020-0943) and prospectively registered on analysis with human members (registration quantity: NL75367.078.20). The requirement for moral evaluation of the interviews was waived underneath the Medical Research Involving Human Subjects Act within the Netherlands by the Medical Ethics Review Committee of Erasmus University MC (registration quantity: 2023-0756), as members weren’t topic to procedures nor required to comply with guidelines of behaviour.

Acknowledgments

The authors are grateful to the examine members and the collaborating normal practitioners.


This web page was created programmatically, to learn the article in its authentic location you’ll be able to go to the hyperlink bellow:
https://bmjopen.bmj.com/content/16/5/e112032
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